Publications

Wang, J., Qiu, Y., Marti, Z., Li, F., Wacker, M., Oldrati, P., Mühlenbruch, L., Jin, L., Zhang, H., Li, T., Roschitzki, B., Faigle, W., Liu, Y., Nguyen, J. Jar-How, L., Haunerdinger, V., Hauri-Hohl, M., Momburg, F., Bauer, J., Rammensee, H.-G., Sospedra, M., Magliozzi, R., Reynolds, R., Walz, J., Martin, R. EBV infection and HLA-DR15 jointly drive multiple sclerosis by myelin peptide presentation. Cell, online 13 January, 2026, doi.org/10.1016/j.cell.2025.12.046 (2026)

Thomas, O.G., Rykaczewska, R., Galešić, M., van der Burgt, R.T.M, Hallén, N., Bronge, Ferro, F., Bronge, M., Marti, Z. Li, Y., Hill Riqué, A., Lin, J., Krstic, A., Gromadzka, A., Levente Szonder, A., Sorini, C., Reina-Campos, M., Sun, T., Rubio Rodríguez-Kirby, L.A., Dumral, Ö., Berglund, R., Pahlevan Kakhi, M., Adzemovic, M.Z., Zeitelhofer, M., Akpinar, B., Tengvall, K., Nilsson, O.B., Holmgren, E., Starvaggi Cucuzza, C., Högelin, A., Gafvelin, G., Fink, K., Castelo-Branco, G., Needhamsen, M., Khademi, M., Piehl, F., Gräslund, T., Alfredsson, L., Lund H., Uhlén, P., Kockum, I., Martin, R., Jagodic, M., Grönlund, H., Ortlieb Guerreiro-Cacais, A., Olsson, T. Anoctamin-2-specific T cells link Epstein-Barr virus to multiple sclerosis. Cell, online 13 January, 2026, doi: 10.1016/j.cell.2025.12.032. (2026)

Qiu, Z., Marti, Z., Jelcic, I., Martin, R. A protocol for the characterization of autoproliferating B- and T cells from persons with multiple sclerosis. STAR Protocols, December 19, 2025 © 2025 The Author(s). Published by Elsevier Inc. doi/10.1016/ j.xpro.2025.104267 (2025)

Jelcic, Iv., Naghavian, R., Fanaswala, I., Mcnair, W., Esposito, C., Calini, D., Han, Y., Marti, Z., Raposo, C., Sarabia del Castillo, J., Oldrati, P., Erny, D., Kana, V., Zheleznyakova, G., Al Nimer, F., Tackenberg, B., Reichen, I., Khademi, M, Piehl, F., Robinson, M.D., Jelcic, Il., Sospedra, M., Pelkmans, L., Malhotra, D., Reynolds, R., Jagodic, M., Martin, R., T-bet+ CXCR3+ B cells drive hyperreactive B-T cell interactions in multiple sclerosis. Cell Reports Medicine, 18;6(3):102027. doi: 10.1016/j.xcrm.2025.102027 (2025)

Docampo, M.J., Lutterotti, A., Sospedra, M., Martin, R. Mechanistic and biomarker studies to demonstrate immune tolerance in multiple sclerosis. Front. Immunol., 2022 Jan 5;12:787498. doi: 10.3389/fimmu.2021.787498. eCollection 2021 (2022)(doi: 10.3389/fimmu.2021.787498.)

Cruciani, C., Puthenparampil, M., Tomas-Ojer, P., Jelcic, Iv., Docampo M.J., Planas, R., Manogaran, P., Opfer, R., Wicki, C.A., Reindl, M., Jelcic, Il., Lutterotti, A., Martin, R., Sospedra, M. T cell specificity influences disease heterogeneity in multiple sclerosis. Neurology Neuroimmunol. Neuroinflamm., 2021;8:e1075 (2021) (doi:10.1212/NXI.0000000000001075.)

Lutterotti, A., Hayward-Könnecke, H., Sospedra, M., Martin, R. Antigen-specific immune tolerance in multiple sclerosis - promising approaches and how to bring them to patients. Front. Immunol., 2021 Mar 22;12:640935 (2021)(doi: 10.3389/fimmu.2021.640935.)

Wang, J., Jelcic, Iv., Mühlenbruch, L., Haunerdinger, V., Toussaint, N.C., Zhao, Y., Cruciani, C., Faigle, W., Naghavian, R., Foege, M., Binder, T.M.C., Eierman, T., Opitz, L., Fuentes-Font, L., Reynolds, R., Kwok, W.W., Nguyen, J., Lee, J.-H., Lutterotti, A., Münz, C., Rammensee, H.G., Hauri-Hohl, M., Sospedra, M., Stevanovic, S., Martin. R. Tightly linked HLA-DR15 molecules jointly shape an autoreactive T cell repertoire in multiple sclerosis. Cell, 183(5):1264-1281; November 25, 2020 a 2020; epub ahead of print on Oct. 2; (2020)(doi: 10.1016/j.cell.2020.09.054. Epub 2020 Oct 21.)

Planas, R., Santos, R., Tomas-Ojer, P., Cruciani, C., Lutterotti, A., Faigle, W., Schaeren-Wiemers, N., Espejo, C., Eixarch, H., Pinilla, C., Martin, R., Sospedra, M. GDP-L-fucose synthase as a novel CD4+ T cell-specific autoantigen in DRB3*02:02 multiple sclerosis patients. Sci. Transl. Med. 2018 Oct 10;10(462). pii: eaat4301 (2018)(doi: 10.1126/scitranslmed.aat4301.)

Jelcic, Iv.*, Al Nimer, F.*, Wang, J., Lentsch, V., Planas, R., Jelcic, Il., Madjowski, A., Ruhrmann, S., Faigle, W., Frauenknecht, K., Pinilla, C., Santos, R., Hammer, C., Ortiz, Y., Opitz, L., Grönlund, H., Rogler, G., Boyman, O., Reynolds, R., Lutterotti, A., Olsson, T., Piehl, F., Sospedra, M., Martin, R. Memory B cells activate brain-homing, autoreactive CD4+T cells in multiple sclerosis. Cell, 175: 1–16; September 20, 2018; epub ahead of print on August 31, 2018 (2018)(doi: 10.1016/j.cell.2018.08.011.)

Lutterotti, A., Martin, R. Antigen-specific tolerization approaches in multiple sclerosis. Expert Opin. Investig. Drugs, 23 (1):9-20 (2014)(doi: 10.1517/13543784.2014.844788.)

Lutterotti, A., Yousef, S., Sputtek, A., Stürner, K., Stellmann, J.-P., Breiden, P., Reinhardt, S., Schulze, C., Bester, M., Heesen, C., Schippling, S., Miller, S.D., Sospedra, M., Martin, R. Induction of tolerance by autologous peptide-coupled cells in multiple sclerosis. Sci. Transl. Med., 5: 188ra75. (2013)(doi: 10.1126/scitranslmed.3006168.)

Lutterotti, A., Sospedra, M., Martin, R. Antigen-specific therapies in MS – current concepts and novel approaches. J. Neurol. Sci. 274: 18-22 (2008) (doi: 10.1016/j.jns.2008.05.021.)